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Immunogenic polypeptide surface layer-expressing bifidobacterium
专利权人:
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
发明人:
Toshiro Shirakawa,Hak Hotta,Takane Katayama
申请号:
US14768508
公开号:
US09925259B2
申请日:
2014.02.14
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Provided is a gene for expressing an immunogenic polypeptide on the cell surface of a bifidobacterium, and the gene includes a gene encoding the immunogenic polypeptide, the immunogenic polypeptide includes a predetermined base domain and at least one antigenic peptide, and the at least one antigenic peptide is linked on any of the N-terminal side and the C-terminal side of the base domain. The gene for expressing an immunogenic polypeptide on a cell surface of a bifidobacterium of the present invention can further include a gene encoding a bifidobacterium-derived GNB/LNB substrate-binding membrane protein.
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