Therapeutic compositions and methods for using same for treating skinconditions and diseases are disclosed. Treatable skin conditions and diseasesinclude without limitation acne vulgaris, rosacea, seborrheic dermatitis,eczema (atopic dermatitis), psoriasis, photo-aging and actinic keratosisacnevulgaris, psoriasis, photo-aging and eczema. Therapeutic compositionsdisclosed are derived from Porifera species, specifically sponges, and morespecifically fresh water sponges. One disclosed embodiment is derived fromSpongilla species and is formulated with pharmaceutically acceptableexcipients.