CARDONA IGLESIAS, PERE J.,AMAT RIERA, ISABEL,REYES, BLANCA,SELGA, ARIADNA,AMAT, MERCE
申请号：
CA2823747
公开号：
CA2823747C
申请日:
2012.01.04
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the Iiposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
