Wucherpfennig Kai W.,Hodi F. Stephen,Franz Bettina,Harvey Christopher,May Jr. Kenneth F.,Dranoff Glenn
申请号：
NZ62981614
公开号：
NZ629816A
申请日:
2014.03.14
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Discloses compositions comprising antibodies and T-cell receptors (CARs) against MHC class I polypeptide related sequence A (MICA) with defined heavy chain variable regions which bind defined epitopes. Discloses that the antibodies/compositions may be used in the treatment of cancer. Binding of the antibodies prevenets MICA mediated down regulation of the NKG2D receptor and increases specific lysis of target cells by NK cells.
