Rachel Slade,Yevgeniya Klimova,Robert J. Halter,Ashantai J. Yungai,Warren S. Weiner,Ruth J. Walton,Jon Adam Willardsen,Mark B. Anderson,Kenton Zavitz
申请号：
US13447115
公开号：
US09034871B2
申请日:
2012.04.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimers disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH2, -L-C(═O)NH(C1-3 alkyl), -L-C(═O)N(C1-3 alkyl)2, -L-S(═O)2(C1-3alkyl), -L-S(═O)2NH2, -L-S(═O)2N(C1-3 alkyl)2, -L-S(═O)2NH(C1-3 alkyl), -L-C(═O)NHOH, -L-C(═O)CH2NH2, -L-C(═O)CH2OH, -L-C(═O)CH2SH, -L-C(═O)NHCN, -L-NHC(═O)ORo, -L-C(═O)NHRo, -L-NH(C═O)NHRo, -L-C(═O)N(Ro)2, -L-NH(C═O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.
