A compound having the structure of Formula VIIa: ** Formula ** in which: R84 is selected from the group consisting of hydrogen and -Cl； R92 is halogen； R94, R95, and R96 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkyl substituted with fluorine, lower alkoxy and lower alkoxy substituted with fluorine； R99 is selected from the group consisting of optionally substituted lower alkyl, optionally substituted phenyl, optionally substituted heteroaryl, and -NR79R80； and R79 and R80 are independently hydrogen or optionally substituted lower alkyl, or R79 and R80 combine with the nitrogen to which they are attached to form optionally substituted 5-7 membered heterocycloalkyl； wherein: lower alkyl indicates a straight or branched chain alkyl containing from 1 to 6 carbon atoms and lower alkoxy indicates the -ORz group, in which Rz is lower alkyl； lower alkyl optionally substituted as R99, R79 or R80, are lower alkyl, optionally substituted with one or more substituents selected from the group consisting of -F, -OH, -NH2, -NO2, -CN, -C (O) OH, -C (S) OH, -C (O) NH2, -C (S) NH2, -S (O) 2NH2, -NHC (O) NH2, -NHC (S) NH2, -NHS (O) 2NH2, - C (NH) NH2, -ORo, -SRo, -OC (O) Ro, - OC (S) Ro, -C (O) Ro, -C (S) Ro, -C (O) ORo, -C ( S) ORo, -S (O) Ro, -S (O) 2Ro, -C (O) NHRo, -C (S) NHRo, -C (O) NRoRo, - C (S) NRoRo, -S (O ) 2NHRo, -S (O) 2NRoRo, -C (NH) NHRo, -C (NH) NRpRc, -NHC (O) Ro, -NHC (S) Ro, -NRoC (O) Ro, - NRoC (S) Ro, -NHS (O) 2Ro, -NRoS (O) 2Ro, -NHC (O) NHRo, -N HC (S) NHRo, -NRoC (O) NH2, -NRoC (S) NH2, - NRoC (O) NHRo, -NRoC (S) NHRo, -NHC (O) NRo Ro, -NHC (S) NRoRo, -NRoC (O) NRoRo, -NRoC (S) NRoRo, - NHS (O) 2NHRo, -NRoS (O) 2NH2, - NRoS (O) 2NHRo, -NHS (O) 2NRoRo, -NRoS (O) 2NRoRo, -NHRo, -NRoRo, -Re, -Rf, and - Rg； optionally substituted phenyl or optionally substituted heteroaryl such as R99, or 5-7 membered heterocycloalkyl optionally substituted as R79 or R80 combined with the nitrogen to which they are attached are
