CARVEN, GREGORY, JOHN,VAN EENENNAAM, HANS,DULOS, GRADUS, JOHANNES
申请号:
HK10106898.8
公开号:
HK1140497B
申请日:
2010.07.16
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
Antibodies which block the binding of human Programmed Death Receptor 1 (hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-1 pathway is also disclosed.