The present invention provides a novel method which can effectively produce a cross-linked hyaluronic acid derivative by washing the cross-linked hyaluronic acid derivative using a washing device equipped with a washing basket. The method can efficiently wash a residual cross-linking agent, and easily collect a washed cross-linked product. A washing method of the cross-linked hyaluronic acid derivative comprises the steps of: putting a cross-linked hyaluronic acid derivative into a washing basket having a mesh injecting a buffer solution into a washing tank washing a cross-linked product in the buffer solution and discharging the buffer solution.COPYRIGHT KIPO 2016본 발명은 가교된 히알루론산 유도체를 세척 바스켓이 장착된 세척 장치를 이용하여 세척함으로써 가교된 히알루론산 유도체를 효과적으로 제조할 수 있는 신규한 방법을 제공하는 것을 특징으로 한다.
