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Method of Cross-Linking Hyaluronic Acid with Divinylsulfone
专利权人:
NOVOZYMES BIOPHARMA DK A/S
发明人:
Fanny Longin,Khadija Schwach-Abdellaoui
申请号:
US14591522
公开号:
US20150190420A1
申请日:
2015.01.07
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to methods of producing a homogenous hydrogel comprising hyaluronic acid, or salt thereof, crosslinked with divinylsulfone (DVS), said method comprising the steps of (a) providing an alkaline solution of hyaluronic acid, or salt thereof; (b) adding DVS to the solution of step (a), whereby the hyaluronic acid, or salt thereof, is crosslinked with the DVS to form a gel; (c) treating the gel of step (b) with a buffer, wherein the gel swells and forms a hydrogel comprising hyaluronic acid, or salt thereof, crosslinked with DVS.
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http://www.ckcest.cn/home/
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