KAWAKAMI, SHIMPEI,川上晋平,SAKURAI, MINORU,桜井稔,KAWANO, NORIYUKI,河野则征,河野則征,SUZUKI, TAKAYUKI,铃木贵之,鈴木貴之,SHIRAISHI, NOBUYUKI,白石宜之,HAMAGUCHI, WATARU,濵口渉,SEKIOKA, RYUICHI,関冈竜一,関岡竜一,MORITOMO, H
申请号：
TW101138258
公开号：
TW201331185A
申请日:
2012.10.17
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention is to provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11beta-hydroxysteroid dehydrogenase type 1 contributes such as dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularly type 2 diabetes), and insulin resistance. It was discovered that a bicyclic heterocyclic compound substituted with an acylamino group such as a (hetero)aroylamino group (the bicyclic heterocycle being formed by condensing a cyclohexane ring and a 5- or 6-membered monocyclic heterocycle having only a nitrogen atom as the heteroatom) or a pharmaceutically acceptable salt thereof has a superior selective inhibitory action with respect to 11beta-HSD1. Thus, the bicyclic heterocyclic compound can be used in the treatment of dementia, schizophrenia, depression, pain (particularly neuropathic pain and fibromyalgia), diabetes (particularly type 2 diabetes), insulin resistance, and the like.本發明為提供作為有關痴呆、精神分裂症、鬱悶、疼痛(特別為神經障礙性疼痛、纖維肌肉痛症)、糖尿病(特別為2型糖尿病)、胰島素抵抗性等11β-羥基類固醇脫氫酶型1有關的疾病治療用醫藥組成物之有效成分為有用之化合物。本發明的解決手段為，發現由(雜)芳醯胺基等醯胺基所取代之二環式雜環化合物(該二環式雜環係由環己烷環、與僅具有作為雜原子之氮原子的5至6員單環式雜環進行縮合所形成)或其製藥學上可被許可的鹽具有對11β-HSD1優良的選擇性阻礙作用。因此，本發明的二環式雜環化合物可使用於痴呆、精神分裂症、鬱悶、疼痛(特別為神經障礙性疼痛、纖維肌肉痛症)、糖尿病(特別為2型糖尿病)、胰島素抵抗等治療。
