A method of forming a coated medical device. The method comprises applying a coating to an outer surface of a medical device by dip coating. The coating includes a therapeutic agent dispersed in a matrix of a polymer or oligomer excipient. The method further comprises post-processing the medical device by immersion in a solvent or solution to selectively remove a substantial portion of the polymer or oligomer excipient from the matrix in which the therapeutic agent is dispersed. The method further comprises sterilizing the post-processed medical device. The coating comprises less than 50% by weight of the therapeutic agent prior to post-processing, and the coating comprises greater than 50% by weight of the therapeutic agent after post-processing. In at least an embodiment, a therapeutic agent, excipient, and solvent system with a desired selectivity to the excipient are selected in order to accurately and reproducibly tune a desired loading of therapeutic agent on the medical device while maintaining suitable mechanical characteristics so that functionality of the coating is not lost during clinical use.
