PROBLEM TO BE SOLVED: To provide a novel agent derived from naturally occurring component which exhibits an excellent effect in maintaining functions of a stem cell, particularly a mesenchymal stem cell, and is excellent in safety.SOLUTION: A stem cell function-maintaining agent contains as an active ingredient extract or a hydrolysate thereof of one or more plant selected from the group consisting of rice, Luffa cylindrica (L.) Roem., Prunus persica, Glycine max (L.) Merr., Callicarpa japonica, Prunus armeniaca, and Alchemilla vulgaris L., and can inhibit oxidation damages of a mesenchymal stem cell to maintain functions of the mesenchymal stem cell.COPYRIGHT: (C)2016,JPO&INPIT【課題】幹細胞、特に間葉系幹細胞の機能維持にすぐれた効果を発揮し、かつ生体安全性にすぐれた天然物由来成分からなる新規な剤の提供。【解決手段】コメ、ヘチマ、モモ、ダイズ、ムラサキシキブ、アンズ、ハゴロモグサからなる群より選択される1又は2以上の植物の抽出物又はその加水分解物を有効成分として含有し、間葉系幹細胞の酸化ダメージを抑制して、当該間葉系幹細胞の機能を維持。【選択図】なし