RAYMON, HEATHER,雷蒙 海瑟,HEGE, KRISTEN MAE,黑格 克利斯坦 梅耶,雷蒙 海瑟,黑格 克利斯坦 梅耶
申请号：
TW103113960
公开号：
TWI604843B
申请日:
2014.04.16
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Provided herein are methods for treating or preventing glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound to a patient having glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status.本文提供治療或預防特徵為O6-甲基鳥嘌呤-DNA甲基轉移酶(MGMT)表現及/或啟動子甲基化狀態之多形性膠質母細胞瘤(GBM)之方法，其包括向罹患特徵為O6-甲基鳥嘌呤-DNA甲基轉移酶(MGMT)表現及/或啟動子甲基化狀態之多形性膠質母細胞瘤(GBM)之患者投與有效量之二氫吡并吡化合物。
