Provided herein are methods for treating or preventing glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound to a patient having glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status.本文提供治療或預防特徵為O6-甲基鳥嘌呤-DNA甲基轉移酶(MGMT)表現及/或啟動子甲基化狀態之多形性膠質母細胞瘤(GBM)之方法，其包括向罹患特徵為O6-甲基鳥嘌呤-DNA甲基轉移酶(MGMT)表現及/或啟動子甲基化狀態之多形性膠質母細胞瘤(GBM)之患者投與有效量之二氫吡并吡化合物。
