Regeneron Pharmaceuticals, Inc.;Institute for Research in Biomedicine (IRB);Yale University
发明人:
Stevens, Sean,Murphy, Andrew J.,Flavell, Richard,Eynon, Elizabeth,Galan, Jorge,Willinger, Tim,Manz, Markus,Rongvaux, Anthony
申请号：
AU2010303737
公开号：
AU2010303737A1
申请日:
2010.10.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene； and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
