Richard Flavell;SEAN STEVENS;Elizabeth Eynon;Anthony Rongvaux;Markus Manz;Andrew J. Murphy;Tim Willinger;Jorge Galan
发明人:
SEAN STEVENS,Andrew J. Murphy,Richard Flavell,Elizabeth Eynon,Jorge Galan,Tim Willinger,Markus Manz,Anthony Rongvaux
申请号：
US13617448
公开号：
US20130024957A1
申请日:
2012.09.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene； and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
