compound, method for treating and / or preventing a disease distinguished by deficient signaling of neurotropins and / or other trophic factors, use of a compound, pharmaceutical composition, combination product, kit of parts, and processes for preparing a compound and a pharmaceutical composition.
The present invention relates to a new use of 4-phenoxy-phenyl-1,3,5-triazine derivatives or pharmaceutically acceptable salts thereof according to formula i, wherein r1, r2 and i have meanings as given in description, as medicines for the treatment and / or prevention of diseases characterized by decreased signaling of neurotrophins and / or other trophic factors. In particular, the invention relates to the treatment of such diseases in patients with the val66met mutation in the brain derived neurotrophic factor gene.a presente invenção se refere a um novo uso de derivados de 4-fenoxi-fenil-1,3,5-triazina ou sais farmaceuticamente aceitáveis dos mesmos, de acordo com a fórmula i, em que r1, r2 e u têm significados como fornecidos na descrição, como medicamentos para o tratamento e/ou prevenção de doenças caracterizadas por sinalização diminuída de neurotrofinas e/ou outros fatores tróficos. em particular, a invenção se refere ao tratamento de tais doenças em pacientes com a mutação val66met no gene do fator neurotrófico derivado do cérebro.
