BOIVIN, DOMINIQUE,CASTAIGNE, JEAN-PAUL -,DEMEULE, MICHEL,TRIPATHY, SASMITA,CURRIE, JEAN-CHRISTOPHE -,LORD-DUFOUR, SIMON -,多米尼克.波依溫,讓-保羅.卡斯泰恩,米歇爾.德默勒,薩斯米塔.塔里帕西,讓-克里斯托夫.柯里,西蒙.洛德-杜富爾
申请号：
HK15100521.1
公开号：
HK1200190A
申请日:
2015.01.16
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds.
