BOIVIN, DOMINIQUE,CASTAIGNE, JEAN-PAUL,DEMEULE, MICHEL,TRIPATHY, SASMITA,CURRIE, JEAN-CHRISTOPHE,LORD-DUFOUR, SIMON
申请号：
EP12853573
公开号：
EP2785837A4
申请日:
2012.11.30
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds.
