MARIA I.C. GYONGYOSSY-ISSA,Jayachandran N. Kizhakkedathu,Iren Constantinescu,William Campbell,Carlos A. Del Carpio Munoz
申请号：
US15143738
公开号：
US20170095421A1
申请日:
2016.05.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.
