MARIA I.C. GYONGYOSSY-ISSA,Jayachandran N. Kizhakkedathu,Iren Constantinescu
申请号：
US15143711
公开号：
US20170095420A1
申请日:
2016.05.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method for producing a composition of lipidic particles coated with a cross-linked surface mesh, the method comprising the steps of: (i) preparing lipidic particles comprising pharmaceutically acceptable lipids, (ii) binding hydrophilic polymer chains to the surface of the lipidic particles, and (iii) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh. Pharmaceutical compositions comprising surface modified lipidic particles prepared according to this method are also described. The lipidic particles resist fusion with red blood cells and platelets in vitro, and are amenable to further derivatization by targeting molecules for controlled release of component and contents, thus providing a new generation of drug carrier systems.
