The present invention relates to pyrimidine diamine derivatives, preparation method and pharmacuetical use thereof. Specifically, the present invention relates to a novel pyrimidine diamine derivative as represented by formula (I), the pharmaceutical salts thereof or the pharmaceutical compositions containing the derivative, and the preparation methods thereof. Furthermore, the present invention relates to a use of said pyrimidine diamine derivative, the pharmaceutical salts thereof or said pharmaceutical composition in preparing a therapeutic agent especially as the Syk kinase inhibitor, wherein the respective substituents of formula (I) are as defined in the specification.本發明涉及嘧啶二胺類衍生物、其製備方法及其在醫藥上的應用。具體而言，本發明涉及一種通式(I)所示的新的嘧啶二胺類衍生物及其可藥用的鹽或含有其的醫藥組成物、及其製備方法，本發明進一步涉及該嘧啶二胺類衍生物及其可藥用的鹽或含有其的醫藥組成物在製備治療劑，特別是Syk蛋白激酶抑制劑中的用途，其中通式(I)的各取代基與說明書中的定義相同。
