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Deamorphization of spray-dried formulations via spray-blending
专利权人:
Novartis AG
发明人:
Weers, Jeffry,Huang, Daniel,Tarara, Thomas,Miller, Danforth
申请号:
AU2014229361
公开号:
AU2014229361A1
申请日:
2014.03.11
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
Dry powder formulations for inhalation and their use in the treatment diseases and conditions. The formulation contains a uniform blend of a first spray-dried powder and a second spray-dried powder. The first spray-dried powder contains spray-dried particles of a therapeutically active ingredient dispersed in a pharmaceutically acceptable hydrophobic excipient. The second spray-dried powder contains spray-dried particles formed from a pharmaceutically acceptable hydrophobic excipient but are substantially free of any therapeutically active ingredient. The active ingredient in the first spray-dried powder is loaded sufficiently high to compensate for the second spray-dried powder being substantially free of any active ingredient. A process for preparing such formulations is also described.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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