AMPHIPHILIC CYCLIC PHOSPHAZENE TRIMER AND HYDROPHOBIC DRUGS MICELLE-ENCAPSULATED BY THE TRIMER

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专利权人:

LTD.;CNPHARM CO.;CNPHARM CO., LTD.;(주)씨앤팜

发明人:

SOHN, YOUN SOO,손연수,JUN, YONG JOO,전용주

申请号：

KR1020110091796

公开号：

KR1020120089991A

申请日:

2011.09.09

申请国别(地区):

KR

年份:

2012

代理人:

摘要：

PURPOSE: A method for preparing an amphiphilic cyclic phosphazene trimer with biocompatibility is provided to improve physiochemical stability, efficacy, and toxicity of a drug. CONSTITUTION: Am amphiphilc cyclic phosphazene trimer is denoted by chemical formula 1&lsqb；N=P(MPEG)(oligopeptide ester)&rsqb；_3. The oligopeptide is C1-6 alkyl ester or C7-C13 aryl alkyl ester of hexapeptide to nanopeptide. The oligopeptide contains hydrophobic amino acids of glycine(Gly), phenyl alanine(phe), leucine(Leu), isoleucine alanine(Ala), alanine(Ala), or valine(Val). The hydrophobic drug is doxetacell or paclitaxel.본 발명은 생체 적합성을 갖는 양친성 고리형 포스파젠 삼합체 및 그 제조 방법에 관한 것이다. 또한 본 발명은 상기 양친성 고리형 포스파젠 삼합체로 미셀(micelle)화한 소수성 약물제제 및 그 제조방법에 관한 것이다.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/