The present invention relates to a kind of analytical equipments, wherein, the system comprises at least one metal guiding devices, one end is equipped at least one set of hole, the hole is directly in conjunction with the reactant to substrate with specificity, the end is threaded end, and its other end what controls the guiding device, and is not necessarily connected with suction system. The guiding device is inserted into the detachable protective system flushed with function end； until micro-analysis and/or microsampling site； and/or the guiding device can be inserted into the medical instrument with internal path, the guiding device can slide wherein. The present invention also relates to this equipment to manufacture the purposes in a kind of tool with the what diagnosis cancer of patient's body, inflammation, infection, neurodegenerative disease or graft rejection, preferably passes through transparietal path. The invention further relates to a kind of methods for analyzing substrate in vitro using this equipment.本發明涉及一種分析設備，其中，所述系統包括至少一個金屬導向裝置，其一端設有至少一組孔，該孔直接與對底物具有特異性的反應物結合，所述端爲穿孔端，而其另一端用於控制所述導向裝置，並且非必須地與抽吸系統相連。所述導向裝置可以插入到與功能端齊平的可拆卸的保護系統中，一直到微量分析和／或微量取樣位點，和／或所述導向裝置可以插入至具有內部通路的醫療器械中，所述導向裝置可以在其中滑動。本發明也涉及這種設備在製造一種用於診斷患者體內的癌症、炎症、感染、神經變性疾病或移植排斥的工具中的用途，優選通過經體壁的路徑。本發明還涉及一種使用這種設備在體外分析底物的方法。
