FORME CRISTALLINE DU MONOPHOSPHATE DE N-[6-(FORME CIS-2,6-DIMÉTHYLMORPHOLINE-GROUPE-4)PYRIDINE-GROUPE-3]-2-MÉTHYL-4'-(TRIFLUOROMÉTHOXY)[1,1'-BIPHÉNYL]-3-FORMAMIDE ET SON PROCÉDÉ DE PRÉPARATION

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专利权人:

Ltd.;Crystal Pharmatech Co.

发明人:

CHEN, Minhua,ZHANG, Yanfeng,LU, Fei,ZHANG, Xiaoyu

申请号：

EP16771385

公开号：

EP3279198A4

申请日:

2016.03.30

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present disclosure relates to novel crystalline forms of N-[6-(cis -2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl)-4'-(trifluoromethoxy) [1,1'-biphenyl]-3-carboxamide monophosphate, and process of preparation thereof. The crystalline form of the monophosphate of a compound of formula (I) has low hygroscopicity, is convenient to store, has better stability than that of diphosphonate in prior art, can avoid the risk of crystal transformation in the development and production of the drug. The preparation method is simple, has low cost, and has important value for further optimization and development of the drug.

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中国工程科技知识中心

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http://www.ckcest.cn/home/