The invention relates to application of high-oxygen water to preparation of medicine for prevention and/or treatment of hyperuricemia. The oxygen content of the high-oxygen water is not less than 20 ppm, and regarding the initial oxygen content of the high-oxygen water being 100%, the difference (A-B) between the percentage (A) of the oxygen content of the high-oxygen water standing for 30 minutes and the percentage (B) of the oxygen content of the high-oxygen water standing for 180 minutes is less than 24%.