Robillard, Marc Stefan,Lub, Johan,Rossin, Raffaella,Van Den Bosch, Sandra Martina,Versteegen, Ronny Mathieu
申请号：
AU2012252024
公开号：
AU2012252024B2
申请日:
2012.05.07
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels- Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has a flattened structure as a result of the position of at least two exocyclic bonds.
