Refers to dihydroxy Aromatic Heterocyclic compounds of formula (i) where X is n CR2 or, where R2 is H, alkyl or aryl Halogen Lower alquileno is lower and Z is n or CH, CH r1 is H, alkyl, halogen (C1 - C10), cycloalkyl, among others.Preferred compounds are: 4 - hydroxy - 2 - {2 - [4 - (trifluoromethyl) phenyl] ethyl} 3 pyridazin-3 (2H) - One 4 - hydroxy - 2 - 6 - [(4-methylphenyl) ethyl] 3 pyridazin-3 (2H) - One 6 - [2 - (Diphenyl - 4-yl) ethyl] - 4 - hidroxipiridazin - 3 (2H) - One among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of d-amino acid oxidase (Daao) being useful in the treatment of schizophrenia, neuropathic painSE REFIERE A COMPUESTOS HETEROCICLICOS DIHIDROXI AROMATICOS DE FORMULA (I) DONDE X ES CR2 O N, EN DONDE R2 ES H, ALQUILO INFERIOR, HALOGENO O ARIL-ALQUILENO INFERIOR Y ES CH O N Z ES CH R1 ES H, ALQUILO(C1-C10), HALOGENO, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-HIDROXI-6-{2-[4-(TRIFLUOROMETIL)FENIL]ETIL}PIRIDAZIN-3(2H)-ONA 4-HIDROXI-6-[2-(4-METILFENIL)ETIL]PIRIDAZIN-3(2H)-ONA 6-[2-(BIFENIL-4-IL)ETIL]-4-HIDROXIPIRIDAZIN-3(2H)-ONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA OXIDASA D-AMINOACIDO (DAAO) SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, DOLOR NEUROPATICO
