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PROTEÍNA QUIMÉRICA COMPOSTA POR DOMÍNIO ANTAGONISTA DE NGF E UM DOMÍNIO ANTAGONISTA DE TNFA
专利权人:
MEDIMMUNE LIMITED
发明人:
申请号:
PT15701985
公开号:
PT3099713T
申请日:
2015.02.02
申请国别(地区):
PT
年份:
2020
代理人:
摘要:
This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising co-administration of an NGF antagonist and a TNFα antagonist. The NGF antagonist and the TNFα antagonist can be separate molecules or part of a multifunctional polypeptide, e.g., a multispecific binding molecule that comprises an NGF antagonist domain and a TNFα antagonist domain. This disclosure also provides multifunctional polypeptides, e.g., multispecific binding molecules, comprising an NGF antagonist domain, and a TNFα antagonist domain. The method provides improved pain control. Administration of an NGF antagonist and a TNFα antagonist as provided herein can control pain in the subject more effectively than an equivalent amount of the NGF antagonist or the TNFα antagonist administered alone.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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