INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS;FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL;FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA
发明人:
Daniel MASPOCH COMAMALA,Antonia María CANO SARABIA,Marta VIVES PI,Irma PUJOL AUTONELL,Juan VERDAGUER AUTONELL
申请号:
US15111466
公开号:
US20160338953A1
申请日:
2015.01.16
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.