Institució Catalana de Recerca i Estudis Avançats;Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol;Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol;Fundació Institut Català de Nanociència i Nanotecnologia
The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.
