The present invention provides an anti－mouse α－9 integrin antibody, an anti－human α－9 integrin antibody, an hybridoma producing said antibody, a method for preparing Said antibody and hybridoma, a medicine composition containing said antibody, etc. The anti α－9 integrin antibody owing to its α－9 integrin inhibition mechanism, is useful for treating cancer disease such as the poliferation and migration of cancer cell, and Inflammation disease, for example rheumatic arthritis, deformed arthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple myeloma, granuloma, Inflammatory enteritis (large intestine ulcerative colitis, clone disease), auto－immune diseaseetc.本發明提供抗小鼠α 9整合素(integrin)抗體、抗人類α 9整合素抗體、產生前述抗體之融合瘤(hybridoma)細胞、前述抗體及融合瘤細胞之製造方法、含上述抗體之醫藥組成物等。本發明之抗α 9整合素抗體係藉由抑制α 9整合素之機能，而對癌，例如癌細胞之增殖、轉移，及炎症性疾病，例如風濕性關節炎、變形性關節炎、肝炎、支氣管氣喘、纖維化症、糖尿病、動脈硬化、多發性硬化症、肉芽腫、炎症性腸疾病(潰瘍性大腸炎、克隆氏症)、及自體免疫疾病等具有治療效果。
