PROBLEM TO BE SOLVED: To provide a novel peptide having excellent inhibitory action to mitochondrial calpain which is effective in prevention or treatment of retinal photoreceptor cell degeneration.SOLUTION: There is provided a peptide having an amino acid sequence consisting of a specific sequence, or a peptide which has an amino acid sequence where one or several amino acids are substituted, deleted and/or added in an amino acid sequence consisting of a specific sequence, and has inhibitory action to mitochondrial calpain, wherein, adding a protein transduction domain to N-terminal of the peptide makes it suitable as an active ingredient for intravitreal injections or ophthalmic solutions for preventing or treating retinal photoreceptor cell degeneration.COPYRIGHT: (C)2014,JPO&INPIT【課題】網膜視細胞変性症の予防や治療に有効な、ミトコンドリアカルパインに対して優れた阻害作用を有する新規ペプチドの提供。【解決手段】特定な配列からなるアミノ酸配列を有するペプチド、または、特定な配列からなるアミノ酸配列において1若しくは数個のアミノ酸が置換、欠失及び/又は付加されたアミノ酸配列を有し、かつ、ミトコンドリアカルパインに対して阻害作用を有するペプチドであって、当該ペプチドのN末端にタンパク質伝達ドメインを付加することで、網膜視細胞変性症の予防や治療のための硝子体内注射剤や点眼剤の有効成分として好適なものにしたペプチド。【選択図】図11
