HADARI, YARON,MANDEL-BAUSCH, ELIZABETH M.,RADKE, SUSANNE,SCHLESSINGER, JOSEPH,YOSHIHISA, SUZUKI
申请号：
TW101102965
公开号：
TW201242978A
申请日:
2012.01.30
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
