Yaron Hadari,Elizabeth M. Mandel-Bausch,Susanne Radke,Joseph Schlessinger,Yoshihisa Suzuki
申请号：
US13358210
公开号：
US20120189633A1
申请日:
2012.01.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
