A device for opening an ampoule includes an ampoule holder configured to hold a body of the ampoule along a central longitudinal axis, a head holder configured to hold a head of the ampoule, and a guide engaged with the head holder and configured to direct the head holder from a first position on the central longitudinal axis to a second position offset from the central longitudinal axis when the ampoule holder is advanced in a first direction along the central longitudinal axis from an initial position. A method for opening an ampoule includes moving the ampoule in a first direction along a central longitudinal axis, directing the head of the ampoule laterally and/or obliquely away from the central longitudinal axis to break the head of the ampoule from the body of the ampoule when the ampoule is moved in the first direction, removing material from the body of the ampoule, and removing liquid from the head of the ampoule.
