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PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES
专利权人:
Seattle Genetics; Inc.
发明人:
JEFFREY, Scott,BURKE, Patrick,HOWARD, Philip, Wilson
申请号:
EP12840661
公开号:
EP2755642B1
申请日:
2012.10.12
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound or (c) R10 is H and R11 is S02M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
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