Heteroaryl derivatives as orexin receptor antagonists

• 收藏
• 分享

专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

HENNER KNUST,MATTHIAS NETTEKOVEN,OLIVIER ROCHE,MARK ROGERS-EVANS

申请号：

BRPI0821141

公开号：

BRPI0821141A2

申请日:

2008.12.11

申请国别(地区):

BR

年份:

2015

代理人:

摘要：

The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/