MODIFIED VARIABLE DOMAIN MOLECULES AND METHODS FOR PRODUCING AND USING SAME

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专利权人:

发明人:

申请号：

EP10824324.7

公开号：

EP2470565A1

申请日:

2010.10.25

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present disclosure provides an isolated protein comprising an antibody heavy chain variable region (VH) comprising a negatively charged amino acid at position 28 and/or 31 and/or 32 and/or 33 and/or 35 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

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