Novel antibodies which bind alpha5beta1 (fibronectin receptor) and uses thereof

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专利权人:

GENENTECH; INC.

发明人:

LIANG, WEI-CHING,PLOWMAN, GREGORY D,WU, YAN,YE, WEILAN

申请号：

NZ58483808

公开号：

NZ584838A

申请日:

2008.09.25

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a humanized anti-á5â1 antibody comprising a light chain variable domain sequence comprising (1) a light chain hypervariable region 1 ("LHVR1") comprising the amino acid sequence KASQ-N/S-VGSDVA (SEQ ID NO:10), (2) an LHVR2 comprising the amino acid sequence STSYRYS (SEQ ID NO:11) and (3) an LHVR3 comprising the amino acid sequence QQY-N/S-SYPFT (SEQ ID NO:12) and a heavy chain variable domain sequence comprising (1) a heavy chain hypervariable region 1 ("HHVR1") comprising the amino acid sequence GYTF-T/S-DYYLY (SEQ ID NO:13), (2) an HHVR2 comprising the amino acid sequence GISPS-N/S-GGTTF-N/A-D-N/A-FE-N/G (SEQ ID NO:14) and (3) an HHVR3 comprising the amino acid sequence DAYGDWYFDV (SEQ ID NO:15).

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