This invention relates to a method for preparing an oil-in-water emulsion comprising mometasone furoate, the method comprising a) preparing an aqueous phase by i) dispersing mometasone furoate in a portion of a mixture of propylene glycol and water, ii) mixing the remaining parts of propylene glycol and water, iii) heating the mixture from step ii) to about 65°C together with sodium citrate and citric acid, iv) adding the dispersion from step i) to the resulting mixture from step iii), b) preparing an oil phase by v) mixing ingredients of the oil phase, and vi) heating the mixture resulting from v) to about 70°C, c) adding the oil phase to the aqueous phase by mixing, d) homogenizing the mixture from c), and e) cooling the emulsion obtained from d) during stirring.モメタゾンまたは医薬的に許容なその誘導体の水中油型エマルジョンの形態の新規な医薬組成物、特にクリーム。該組成物は、優れた安定性と治療効果を有する。該組成物は微粉末の形態のモメタゾン、プロピレングリコールおよび水を含み、水中油型エマルジョンに含まれるプロピレングリコールと水との間の重量比は1:1~約1:3である。【選択図】なし
