UNIVERSITAET DUISBURG-ESSEN;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI;YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
发明人:
Edward H. Schuchman,Erich Gulbins,Anthony Futerman,Yael Pewzner-Jung
申请号：
US15286327
公开号：
US20170020998A1
申请日:
2016.10.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
