Guillaume El GLAOUI,Mehdi El GLAOUI,Philippe PERRIN,Stéphane DROUPY,Véronique AGATHON-MERIAU
申请号：
US16362081
公开号：
US20190290615A1
申请日:
2019.03.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to non-hormonal compositions and methods for inducing a condition of aspermia, azoospermia, or severe oligozoospermia in the male subject such that these compositions and methods for administering the same may be used as male contraception. Embodiments of the present invention may comprise a composition comprising an alpha-1-adrenoreceptor antagonist, such as (R)-silodosin, for daily administration to a male subject. The compositions and related methods may further include pharmaceutically acceptable carriers. The present invention further includes formulations which allow for a delay such that delayed or missed dose(s) do not nullify the contraceptive effect of the treatment regimen. Such compositions and methods may also avoid the side effects associated with typical formulations of alpha-1-adrenoreceptor antagonists.
