For use in reducing the Proliferation of cancer cells and enhance the effectiveness of chemotherapy drugs.Claim 1: a compound for use in reducing the Proliferation of cancer cells, wherein the compound has the General formula (1),Where r\u00b9 is selected from the group consisting of hydrogen, substituted or unsubstituted cycloalkyl substituted alkyl, substituted or non substituted, alquenilo replaced or not replacedAryl substituted or unsubstituted arylalkyl substituted or non substituted, non Aromatic, heterociclilo replaced or not replaced, heterociclilo Aromatic substituted or non substituted,Heterociclilalquilo replaced or not replaced, cor\u2078 -, - C (o) or\u2078, - C (o) nr\u2078r\u2079, - ch = nr\u2078, - CN, - or\u2078, OC (or r\u2078) - S (o) \u209c r\u2078 nr\u2078r\u2079 -, -, - nr\u2078c r\u2079 - no\u2082 (,, OR)- n = cr\u2078r\u2079 and Halogen R\u00b2 is selected from the group consisting of hydrogen, substituted or unsubstituted cycloalkyl substituted alkyl, substituted or non substituted, alquenilo replaced or not replacedAryl substituted or unsubstituted arylalkyl substituted or unsubstituted, heterociclilo Aromatic or non Aromatic, substituted or non substituted, heterociclilalquilo replaced or not replaced - cor\u2078,Or\u2078, - C (o) - C (o) nr\u2078r\u2079, - ch = nr\u2078, - CN, - or\u2078, OC (or r\u2078) - S (o) \u209c r\u2078 nr\u2078r\u2079 -, -, - nr\u2078c (OR) r\u2079, no\u2082 -, - n = cr\u2078r\u2079 and Halogen and r\u2074 r\u00b3 is independently Selected from the group consisting of hydrogen,Alkyl substituted or unsubstituted cycloalkyl, replaced or not replaced, alquenilo replaced or not replaced, substituted or unsubstituted arylalkyl substituted aryl, substituted or non substituted,Heterociclilo Aromatic or non Aromatic, substituted or non substituted, heterociclilalquilo replaced or not replaced, cor\u2078 -, - C (o) or\u2078, - C (o) nr\u2078r\u2079, - ch = nr\u2078, - CN, - or\u2078, OC (or r\u2078) - S (o) \u209c - r\u20
