An aiming device for targeted drilling of a hole into bone includes a slot hole extending through the aiming device, the slot hole being configured to receive a guide sleeve therein at different locations therein and at different angles each of which corresponds with one of the locations along a longitudinal extension of the slot hole. The aiming device can be positioned relative to a bone plate using a positioning device including a base having a guide hole extending therethrough from a first side of the base to a second side of the base. The guide hole is formed as an elongated hole and is configured to receive the guide sleeve therein at different angles relative to the positioning device.