A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided.A compound represented by the general formula (I):wherein RX is a group represented by the formula:wherein R1 is a hydrogen atom, optionally substituted alkyl, etc.； Z is —O—, —N(R10)—, etc.； R10 is a hydrogen atom, alkyl, etc.； R2 is a hydrogen atom, optionally substituted alkyl, etc.； R18 is a hydrogen atom, optionally substituted alkyl, etc.； R19 is optionally substituted alkyl, etc.； W1 is an optionally substituted non-aromatic nitrogen-containing group； R17 is a hydrogen atom, optionally substituted alkyl, etc.； R3 and R4 are independently a hydrogen atom, optionally substituted alkyl, etc.； X is —O—, —S—, or —N(R12)—, etc.； R12 is a hydrogen atom, alkyl, etc.； and A is phenyl optionally having a substituent, etc.,its pharmaceutically acceptable salt, or a solvate thereof.
