A medical instrument holding device for holding instrument of different axial cross sections comprising a holding site unit, comprising a plurality of holding sites at predefined holding angles around an axis, the holding sites comprising different holding sizes for holding parts of instruments of different axial cross sections and a coupling unit constituted to define a plurality of coupling angles around the axis with respect to a device support, the coupling unit being constituted to block rotational movement around the axis and to allow coupling of the holding site unit to the device support only at the plurality of coupling angles, when coupled to the device support.
