#$%^&*AU2013273659A120140116.pdf#####Abstract The present invention provides methods of treating creatine responsibve states, such as neurological disorder (i.e., Huntingtons disease, Parkinsons disease, amyotrophic lateral sclerosis and creatine transporter defect) or a skin disorder, by administering a creatine-ligand compound, alone or in combination with an anti-inflammatory compound, to a subject.