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pro-neurogenic compounds
专利权人:
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
ANDREW A. PIEPER,JEF K. DE BRABANDER,JOSEPH M. READY,STEVEN L. MCKNIGHT
申请号:
BR112015003919
公开号:
BR112015003919A2
申请日:
2012.08.24
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
abstract this technology relates generally to compounds and methods for stimulating neurogenesis (e.g., postnatal neurogenesis, including hippocampal postnatal and hypothalamic neurogenesis) and / or protecting neuronal cell from cell death. various compounds are disclosed herein. in vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and / or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, parkinson's disease, alzheimer's disease, down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuroactive drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like. abstract of the patent summary: "pro-neurogenic compounds". The present invention relates generally to compounds and methods for stimulating neurogenesis (e.g., postnatal neurogenesis, including hippocampal and postnatal hypothalamic neurogenesis) and / or neuronal cell protection from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and / or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, posttraumatic stress disorder, parkinson's disease, alzheimer's disease, down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, huntington's disease, stroke, radiation therapy, chronic stress, neuroactive drug abuse, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight associated with various conditions, as well as cognitive decline associated with normal aging, and chemotherapy.abs
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